Identifying the constraining factors of production and yield gap is very important. Therefore; this research was performed to identify the production constraining factors of local rice cultivars. All management practices from nursery preparation to harvesting stages for 100 paddy fields of local rice cultivars were recorded through field studies, in Sari, from 2015-2016. In the CPA, the actual and calculated potential yield were 4495 and 5703 kg/ha, respectively and the gap was 1221 kg/ha. The yield gap caused by number of top-dressing variables was 324 kg/ha, equal to 27% of the total yield gap. The yield gap related to previous year of legumes cultivation was 218 kg ha-1, equal to 18% of the total yield variation. Among the 10 variables entered in the CPA model, the effects of top-dress fertilizer application and its application frequency and foliar application were remarkable, which could compensate a significant part of the yield gap (444 kg/ha, 37% of total) in the farmers’ fields by managing these variables. According to boundary line analysis (BLA) finding, actual yield mean on the basis of optimal limit related to 12 variables under study was 5369 kg/ha, with 881 kg/ha yield gap . Mean relative yield and relative yield gap for 12 variables (transplanting date, seedling age, number of seedlings per hill, planting density, nitrogen and phosphorous per hectare, nitrogen before transplanting, harvesting date, lodging problem, pest problem, diseases problem and weeds problem) were 83.64 and 16.35 kg/ha, respectively. Based on the finding, it can be stated that the model precision is appropriate and can be applied for both estimation of the quantity of yield gap and determining the portion of each restricting yield variables.

Developments in transportation industry and computer science have caused the production of cars that do not need human drivers, and instead are driven by artificial intelligence. In this case, the programmer has to predict the situations in which a potential accident is expected previously and provide training to ensure the self-driving cars’ reactions are in compliance with the law. In possible scenarios, which could occur during driving, reacting in compliance with the law is a fundamental challenge that should be settled by lawyers so that the programmer set the self-driving car’s algorithms according to the lawyers’ proposal in a way that probable accidents do not lead to his/her criminal responsibility. Considering this fact, in the present article by using library resources and through a descriptive-analytic method, depiction of potential scenarios, including cases in which the self-driving car is set up to make a choice between hitting two distinct groups of people is dealt with. Finally, paying attention to foundations of domestic law and precedents relative to homicide-by-necessity in common law system, we are seeking to answer these challenges. As such, it is attempted to present the necessary theoretical perspective in order to make Iran’s legal system ready for the entry of self-driving cars and to reduce the risk for designers and investors’ activities in this field through eliminating the criminal responsibility caused by accident of self-driving cars with human based on necessity rule.

The relationship between knowledge and value is a subject of interest within the realm of transethics. To that end, Soroush has put forth the theory of knowledge and value separation. The purpose of this article is to delineate the fundamental components of Soroush’s theory through the application of descriptive-analytical methodology. Five factors, according to the research findings, influenced Soroush’s conception of this notion: adhering to positivists’ definitions and differentiations of sciences; the notion that the deduction of “must” from “is” violates the principles of logic; believing that values are nothing more than credits; consider scientific ethics to be an impersonal branch of ethics; the conviction that scientific ethics and determinism are inextricably linked. As evidenced by the research findings, deriving “oughts” from “beings” does not necessitate a connection between knowledge and value; rather, it enables the development of ethics through reliance on facts (beings) rather than determinism and impersonality. In reality, the moral provisions are the same necessity that exists between human action and its consequences. Science can also encompass non-experimental knowledge; it comprises experimental knowledge as well as intellectual, mystical, narrative, and philosophical knowledge.

Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development during pathogenesis. The purpose of our study was to determine the expression level of CTGF mRNA in patients with colorectal cancer (CRC). Methods: paraffin embedded tissues from 122 patients with colorectal cancer and their matched normal colon tissues and 20 paraffin embedded normal tissues blocks from normal individual were collected from Taleghani and Shohada hospital in Tehran. The fold change of CTGF expression was analyzed by quantitative real time PCR method, using REST and Prism softwares. Also, LinReg PCR software was also used for the efficiency of primers. Results: We found that expression of CTGF gene in tumor tissue was significantly higher than in adjacent normal tissue (P<0. 0001, RQ>2). A Significant increase was also observed in the expression of this gene in right-sided colon cancer than left side. Conclusion: The findings indicated that the expression pattern of CTGF gene is significantly altered in the development of cancer from normal tissue. Thus, according to major role of CTGF gene in fibrosis, inflammation and connective tissue remodeling, it may be effective in various diseases process including cancer.

In most juridical books and under “usurpation”, “retaliation” and “blood-money” chapters, jurisprudents have spoken of the two institution of “perpetration” and “causation” and enacted some rules, for example if both cause and the actual perpetrator exist, the actual perpetrator is responsible unless in cases in which cause is stronger. The two have been reflected in laws as well. Regarding perpetration, causation, and types of perpetration and etc., many discussions have been made in juridical and legal books. Some scholars such as Muhaqqiq Najafi (author of Jawahir al-Kalam) and Muhaqqiq Maraghi (author of ‘Anawin), however, are of the opinion that, since the terms “cause” and “the actual perpetrator” have not been used in hadiths and there is controversy between jurisprudents about definitions and instances of the two terms, discussion about causation and perpetration is a superfluous and verbal one and what is of importance is attributing damage or crime to someone, whether he is the actual perpetrator or cause. The present article studies and evaluates the scientific and practical differences which may be between the two institutions. Evidently, if it is proved that there are such differences then establishment of these two institutions and discussing about them are required. Otherwise, one has to accept the opinion of the author of Jawahir al-Kalam and the author of ‘Anawin according to whom discussing about the two is a superfluous one.

The Muslim logicians have described the necessity term in the necessity signification as three different levels: The absolute necessity, The evident necessity as its general term, and the evident necessity as its specific term. Using the descriptive analytical method, this journal has proved that by conditioning these levels, this signification wouldn't include six groups of concepts: 1- external non-necessary concepts 2- non-predicated concepts 3- particular concepts 4-separable accidents 5- non-evident(as its general term) necessary accidents 6- non-evident(as its specific term) necessary accidents that are not evident accidents(as its general term). These concepts can't be included in expression signification as well because they wouldn't be placed in the signification of complete or partial accord. The logicians' models for a bipartite division of expression signification aren't flawless and don't point out a solution for the universality of the division. Therefore, this journal has introduced a new division for expression signification in which the third group(after two groups of complete and partial accord significations) is called "external signification" and it includes the signification of necessity as its subsequent.

There is a disagreement between Ibn Sina and Khadjeh Nasir in analyzing universally negative conditionals. Ibn Sina considers them as “negation of necessity”, while the latter thinks of them in terms of “necessity of negation”. Khadjeh Nasir emphasizes the difference between the two positions, and deems the former more general than the other one, but Qutb Razi claims that, according to Ibn Sina’s works, they are equal, despite their difference in meaning.The author in this article tries to show first, in the discussion between Khadjeh and Razi, Khadjeh Nasir is right; second, by reformulating Ibn Sina’s arguments, one can realize an important formal flaw in his analysis; third, Ibn Sina’s answers to this flaw are not acceptable; forth, one may find another answer to this problem by the help of Ibn Sina’s analysis, but it also falls short of resolving the issue. Therefore, the question remains open for further endeavors.